We present Proteina-Complexa, a novel fully atomistic protein binder design framework unifying conditional generative modeling and optimization. This page is partitioned into two sections: Core model development and wet lab validation. We carried out an experimental design campaign with over 1 million binder candidates for 133 targets in collaboration with Manifold Bio, Viva Biotech, Novo Nordisk, Duke University, Cambridge University and LMU Munich

Really great collaboration between @ManifoldBio and @nvidia to test 1M de novo designed binders against 127 targets, measuring over 100 million potential protein-protein interactions! This was a great collaboration with some very exciting results. NVIDIA's new Proteina-Complexa method is SOTA for de novo minibinder design.